Lotrimin … the name sounds very familiar and you’ve heard about the product, perhaps even on TV. It is easily accessible as most drugstores carry it, and readily available on Amazon for those who don’t have the time and inclination to visit the local pharmacy. But should folks with angular cheilitis opt to purchase it?

Lotrimin Advantages

Lotrimin’s active ingredient is clotrimazole which is effective against many types of fungal infections. In fact, Lotrimin is typically used for conditions such as athlete’s foot, jock itch, ringworm, and a host of others where bellicose fungi present issues. Now many doctors feel that Lotrimin can also be a useful anti-perleche product as cheilitis may be caused by yeast/fungi.

The cream, which is the vehicle that is commonly recommended, is also rather affordable, and should be less than $25 – and sometimes much cheaper. Amazon is usually the most cost-effective vendor.)

As Lotrimin is accessible, affordable, and contains the right active ingredient, it may prove to be an excellent perleche option. This doctor, appearing on the video, seems very much in favor of its use for his perleche patients.

Another positive of the product is that it won’t take long before you know whether or not it is effective. In fact, if the condition does not get better in about 2 weeks with Lotrimin’s use, it makes sense to contact your physician to discuss the lack of progress, and perhaps obtain a stronger antifungal agent. (Lotrimin should not be used indefinitely.)

The downside of Lotrimin

While many report favorable results using Lotrimin, the cream may be totally ineffective for some. Of course, if the perleche is not due to yeast infiltration but bacterial in nature, it would appear that Lotrimin will have little, if any, effect. This may be one of the reasons why Lotrimin does not receive a universally favorable rating. Those with ‘bacterial perleche’ need to use an antibacterial, and not antifungal, agent.

To compound matters, Lotrimin, like almost every medicine, may cause side effects. (This is why you should always discuss what treatments you’re using with your physician.) Although it’s rare, Lotrimin can cause burning, itching, swelling, hives, stinging, etc. Of course, if such symptoms manifest, stop using Lotrimin immediately.

Lotrimin AF vs. Lotrimin Ultra

Alright, so you’re ready to try Lotrimin but you’re uncertain whether to use Lotrimin AF or Lotrimin Ultra. This question is better posed to your family physician or even the company itself (although they may state that their product is not designed to treat perleche).

The difference between Lotrimin AF and Lotrimin Ultra appears to be the active ingredient. The former contains clotrimazole, and the latter contains Butenafine hydrochloride. Both are angifungal agents but there seem to be more online reports, citing the effectiveness of clotrimazole. Consequently, try the Lotrimin AF and see what transpires.

Lotrimin Application

Make sure your hands are spotless, thoroughly clean of germs, and gently apply Lotrimin to the affected areas around the mouth. You can reapply it several times a day but just make sure any ‘licking the lips habit’ is contained. The saliva will continue to provide unwanted moisture where the fungi can thrive. Observe results and take appropriate action afterwards.


Lotrimin will not work for every perleche victim, but for those who have angular cheilitis due to yeast, it makes sense to use this in a trial and error fashion. It won’t break the bank, and even if it does not work on your cheilitis, it may prove effective for any future yeast-related conditions that raise their ugly head in the future.

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